35 To what extent these parallel observations are relevant for the specificity of the immune response in PSC can currently only be speculated.
Currently, it is speculated that acquired immune dysfunction in the uremic milieu may be one of the main pathogenic factors, mediated through CVD and infections, in most ESRD-related deaths.
Currently, it is speculated that patients with mutant forms of the PLA2G6 gene display a complete absence of protein, which is associated with a severe INAD profile, whereas patients with compound heterozygous mutations potentially exhibit residual protein function and have a less severe phenotype [ 18].
3 While the superior radiographic results and drug adherence in the infliximab group apparently had little impact on costs and utilities over 2 years, it can currently only be speculated whether such differences could lead to differential physical function or pain in the respective treatment arms and thereby alter the health economic conclusions in the longer term.
While the exact mechanism by which rRNA are not amplified is currently unknown, it is speculated that the secondary structure of rRNA is likely responsible for inefficient primer binding resulting in low cDNA conversion efficiency and minimization of rRNA amplification.
Whereas it is well established that mC is a crucial epigenetic marker [3], the function of the sixth base hmC is currently unknown, but it is speculated that it is involved in epigenetic regulation events or in active demethylation processes [4], [5], [6], [7], [8].
The pathophysiology of this syndrome is currently unclear, but it has been speculated that a combination of high-dose propofol with endogenous as well as exogenously administered catecholamines and/or glucocorticoids may act as a trigger.
The long-term mortality rates in the currently analyzed subgroup with such high failure rates can only be speculated upon.
It is currently unknown what causes manifestation of HPE in genetically at risk individuals, but it has been speculated that environmental factors might play a role.
It's exactly what was speculated yesterday.
