Metastatic renal cell carcinoma (RCC) is a heterogeneous disease, and the selection of treatment and the prediction of outcome are currently based mainly on tumor histology.
NOVA1 can be used as a molecular marker to differentiate low-grade astrocytoma from low-grade oligodendroglioma, and therefore, may be helpful for the refinement of the diagnosis currently based mainly on histopathological characteristics.
Therefore, further analysis of differential protein profiles of these glioma types may help to: 1) refine the histopathologic diagnosis, currently based mainly in morphologic characteristics, with large interobserver variability [ 17, 18], and 2) detect molecular targets that may explain the difference of clinical outcome between low grade astrocytoma and oligodendroglioma.
Information retrieved from open-air sites is necessary for a more complete reconstruction of Middle Paleolithic behaviors, which is currently often based mainly on data from caves and rockshelters.
However, the currently available materials based mainly on polymethylmethacrylate (PMMA) still encounter certain limitations, such as time-consuming polymerization, thermal and chemical necrosis and troublesome revision procedure.
Currently, tissue engineering strategies are based mainly on cell and tissue-based approaches.
Currently available commercial assays are based mainly on HEV epidemic strains but EIA tests specific for genotypes 3 and 4 have also been developed.
Currently, patients are diagnosed with TB based mainly on clinical symptoms, X-rays, and conventional laboratory tests, such as bacterial cultures and sputum smear acid-fast staining, which exhibit much lower sensitivity.
Currently, the diagnosis of AKI is based mainly on an increase in the serum creatinine (SCr) level, which indicates loss of excretory renal function according to the Risk, Injury, Failure, Loss, and End-stage Kidney disease (RIFLE) [ 5], Acute Kidney Injury Network (AKIN) [ 6], and Kidney Disease: Improving Global Outcomes (KDIGO) criteria [ 7].
Currently, only a few self-illuminating probes were developed, based mainly on toxic quantum dots such as CdSe, CdTe.
Glenny's portrait is based mainly on hours of conversation held in the federal prison where Nem currently resides – a context that, as the author admits, led him to develop an "intense relationship" with his subject.
