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If the repeat-driven mechanisms currently active in creating functional CTCF-binding events were also active in the common mammalian ancestor, then ancestral expansions would eventually become shared binding events in descendant species, such as our study species.
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Together, our results support a repeat-driven mechanism for functional CTCF-binding expansion, which is currently active in multiple mammals and was active in our common ancestor, thus creating the CTCF-binding events shared across mammals.
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