Its current trainer, Richard Dutrow, is even more notorious for pushing the envelope.
He worked a series against the Washington Nationals in June while the current trainer, Steve Donohue, attended his daughter's graduation.
Stoute, though, now has five Derbys to his name, making him the most successful current trainer in the race.
He is no longer an official employee of the U.S. national team, but remains close with the current trainer (a protégé) and many of the players.
With Stay Thirsty and Uncle Mo both entered in this year's Classic, Pletcher has a big chance to pick up his third career major and lose the title of "best current trainer never to win the Classic".
Elaine Burke, Libertarian's current trainer, will saddle him one last time when he contests the Irish Derby at The Curragh on 29 June, but after that, he will be stabled in Newmarket with the rest of the Godolphin string.
The colt, whose sire Halling was formerly a leading stallion for the Sheikh's Darley Stud, will now race in Godolphin's blue silks for the remainder of his career, but remain with his current trainer John Gosden in Newmarket.
Sam's Welsh father Nigel is the only current trainer to have saddled two winners of the big race - Earth Summit (1998) and Bindaree (2002).
Nigel Twiston-Davies, the only current trainer to have won two Grand Nationals, with Earth Summit (1998) and Bindaree (2002), looks for a third with top-weight Imperial Commander.
It was a perfect 61st birthday present for Henderson, who is the most successful current trainer at the Cheltenham Festival with 37 wins.
