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The Connor Stevens (CS) model [25] is built upon the Hodgkin–Huxley formalism and comprises a fast Na+ current, a delayed K+ current, a leak current and a transient K+ current, termed the A-current.
These channels activate in response to hyperpolarization to generate an inward current termed If ("funny") in cardiac cells, Ih ("hyperpolarization -activated) in neurons, or Iq ("queer").
This process is initiated by an increase in cytosolic pH, which in mouse spermatocytes activates Ca2+-permeable CatSper channels [3] and, in concert, a pH-regulated K+ current termed KSper [4].
Hyperpolarization-activated cyclic nucleotide-gated channels (HCN1-4) comprise an ion channel family of four distinct members that pass a current termed Ih or If [1], [2], [3], [4].
This transient opening gives rise to a large inward tail current termed 'resurgent current' (Cannon and Bean, 2010).
Other receptors of this type can excite neurons by inhibiting the subthreshold voltage-gated K+ current termed the "M-current" (Delmas and Brown 2005), which normally acts as a brake on firing activity.
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