Tunneling currents become a major problem with shrinking device geometries.
In the case of massively parallel sequencers, the high read error rate of the current technologies is a major problem.
Students with irregular menstrual cycles, current major medical and psychological problems, those receiving hormonal therapy and experiencing a catastrophe shortly before or during the study were excluded from the study.
The major problem of current drug-based therapy is selectivity.
Understanding social dynamics that govern human phenomena, such as communications and social relationships is a major problem in current computational social sciences.
The current situation might become a major problem if those existing shops which maintain the image and identity of the area are substantially displaced by 'outside' retailers who can afford the increased rents.
A major problem for current gene expression analysis is, given the disparity between the number of genes measured (typically, thousands) and number of individuals sampled (typically, dozens), how to identify the handful of genes which, individually or in combination, help classify individuals.
Given recent progress, however, we suggest that the major problem for current microarray research is no longer validity of expression measurements, but rather, the reliability of inferences from the data, an issue more appropriately redressed by statistical approaches than by validation with a separate method.
Another major problem of current eQTL studies is the correct identification of the causal genes.
A major problem with current drugs that target NRs is the side-effects that arise due to unwanted modulation of the targeted NR in tissues that are not the source of the problem, or to the targeting of other NR members of the same class.
