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We agree that the selection of non-moonlighting proteins is based on our current knowledge of function of the proteins and it is possible that secondary function may be found for the proteins in the future.
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This review summarises the current knowledge of hERG function and dysfunction, and the areas of ongoing research.
Based on current knowledge of the function of genes in the gemcitabine pathway, these genes are believed to play a role in response to the drug gemcitabine (http://www.pharmgkb.org/do/serve?objId=PA2036&objCls=Pathway).
Based on the current knowledge of HDAC6 function, some hypotheses appear especially reasonable (Fig. 5).
While all of these findings are in line with our current knowledge of the function of these features, it is difficult to make final biological conclusions due to redundancy between features.
The current knowledge of the function of molecular pathways, the clinical behavior of rhabdoid tumors and our presented results make combined targeted therapy highly attractive and necessary for rhabdoid tumors.
Based on the current knowledge of gene function it was possible to relate the prognostic genes to biological characteristics that have been associated with metastasis development in cervical cancers and thereby propose molecular mechanisms underlying these characteristics.
Although the underlying mechanism for BiP-mediated increases in water-stress tolerance is not completely understood, the current knowledge of BiP function accommodates the argument that it may act in both mechanisms.
The overlap between phenotypes resulting from knockdown of PARD3 and the phenotypes in F9 and F19 is interesting, however we judged that the current knowledge of the function of PARD3B is insufficient to categorize the mutations identified in our cohort as being possibly causal.
Current knowledge of the function of its orthologous genes, its expression profile in Vitis varieties and the strong association between its sequence variation and the degree of seedlessness together indicate that the D-lineage MADS-box gene VvAGL11 corresponds to the Seed Development Inhibitor locus described earlier as a major locus for seedlessness.
Based on the current knowledge of the function of the corresponding proteins, the brain's immune phenotype found in the APPSw mice is more likely to be associated with matrix restructuring and down-regulation of classical inflammatory signalling rather than toxicity (Gordon, 2003; Colton, 2009).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com