Currently, structural information is available for relatively few of the protein kinases encoded in the human genome (7% of the estimated 518); however, even the current knowledge base, when paired with structure-based design techniques, can assist in the identification and optimization of novel kinase inhibitors across the entire protein class.
Unfortunately, the paucity of studies on how to manage TRD in adolescents reveals a gap between the current knowledge base and the need for evidence-based data to guide clinical care.
These scenarios represent the current knowledge base and are reflective of the types of genetically-based information used in decision-making today.
As a result, a comprehensive understanding of human encephalitis, as generated through high quality evidence-based studies and statistical analyses is limited and much of the current knowledge base lacks generalizability [ 2, 9- 11].
Godfrey's hopes for this kind of research are years, possibly decades, beyond the current knowledge base.
Short cuts with homology modeling cannot be taken with our current knowledge base.
This review explores the current knowledge base of the antigenic sites of the H5N1 HA molecule.
The findings and their limitations are discussed alongside implications for future research needed to fill a void in the current knowledge base.
This revelation has come to me a little late—I only have one more year at Cornell, which means that adapting to a new field, though somewhat related to my current knowledge base, is indeed not easy.
This paper outlines the different types of surrogacy and the legal issues facing gay men who choose this route to parenthood, summarizes the limited research on gay men and surrogacy and discusses gaps in the current knowledge base.
In an effort to increase the current knowledge base regarding the manatee immune system, the production of an important reactive nitrogen intermediate, nitric oxide (NO), by manatee peripheral blood mononuclear cells (PBMC) was investigated.
