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The aim of this commentary is to describe current hindrances to field's progress, (some unique to metabolomics, some common with other omics fields or with conventional targeted bioanalysis) to propose some potential solutions to overcome these constraints and to provide a future perspective for likely developments in the field.
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Another hindrance of current modeling attempts is that those systems operate in a parameter space that seems far removed from biological reality.
The current situation is a hindrance to policy decision makers as it prevents fully transparent decision making and the development of more advanced decision support systems.
The random coupling of oligoglycine provides a convenient means of overcoming this apparent steric hindrance but the current data does not provide sufficient evidence to identify the optimum linker length for planar surfaces or Affigel.
Treatment related primary and acquired chemo- radioresistance presents a significant hindrance for all current therapy regimes in pancreatic cancer patients [ 23, 24].
Recognising that the current inconsistency is a serious hindrance to progress in our specialty, the editors of over 50 journals related to women's health have come together to support The CROWN (CoRe Outcomes in WomeN's health) Initiative.
An obvious steric hindrance effect on the current efficiency was also observed in the reduction of substituted-hydroxymethyl groups attached to the 2-position.
Steric hindrance could fit the current model as the proposed JH1-JH2 interactions may physically hinder the access of ATP to the kinase domain and increase the amount of ATP required for the reaction to occur.
Finally, the current status of industrial application is presented, possible hindrances for the adaptation of the technology are discussed, and future directions of development are indicated.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com