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Conclusion: The combination of short cervical length, previous preterm birth caused by preterm premature rupture of membranes, and positive fetal fibronectin screening results was highly associated with preterm delivery caused by preterm premature rupture of membranes in the current gestation.
Univariate analysis revealed low body mass index, pulmonary disease, contractions within 2 weeks, short cervix (≤25 mm), positive results of fetal fibronectin screening, bacterial vaginosis, and a previous preterm birth caused by premature rupture of membranes (in multiparous women) to be significantly associated with preterm birth caused by premature rupture of membranes in the current gestation.
Access to her previous records revealed that she previously presented with haemoptysis at 16 weeks of the current gestation.
Exclusion criteria were: gestational diabetes, maternal heart diseases, changes in foetal morphology found by ultrasound, other factors that could attribute risk to current gestation, hypertensive disorders.
At the local centers, trained nurses interview the participants to gather information regarding their demographic and socioeconomic characteristics, complications related to the current gestation period, health behaviors and environmental factors.
Higher risk of LBW recurrence was observed among mothers with higher parity (≥3 previous deliveries; PR=1.93; 95% CI 1.23-3.02); whadhad given birth to a previous preterm baby (PR=4.01; 2.27-7.10); who delivered a female newborn in current gestation (PR=2.61; 1.45-4.69); and that had not received adequate antenatal care (PR=2.57; 1-37-4.81).
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Women who receive progesterone therapy early for early pregnancy support (prior to 16 weeks gestation) in the current pregnancy will be eligible for trial inclusion.
The assessments for study I (sample I) consisted of the first pilot version of the TPDS and several customized questions regarding demographics (age, marital status, work, education, socio-economic status), obstetric history (parity, previous abortion, term of gestation, complications during current pregnancy and location of delivery) and lifestyle (alcohol use, smoking habits).
Current gestational age thresholds for stillbirth vary from 16 to 28 weeks of gestation across countries.
Data on current pregnancy include information on duration of gestation at the time of abortion, indication for abortion, and method of termination.
The current pregnancy developed signs of NIHF at 19 weeks of gestation, but detailed ultrasonographic examination was nonspecific otherwise.
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