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The resulting gating current exhibited a rising phase similar to that measured in voltage-dependent ion channels.
The fitting results suggested that the leakage current at the lower voltage region showed a linear dependence on voltage, whereas at voltages higher than 0.7 V, the current exhibited a dependence on the square of voltage.
Under the optimized conditions, CV was used for the quantitative detection of HMX, and the reduction peak current exhibited good linear dependence with the concentration of HMX in the ranges of 2 ∼ 20 μM and 20 ∼ 100 μM.
Another inward current exhibited a complete inactivation (control of Fig. 6C & 6D).
Evoked TRPV3 current exhibited an extraordinarily steep dependence on citral concentration (Hill coefficient of 22.3, compared to 1.6 for TRPM8 and 2.7 for TRPV1).
The fast action potential current exhibited the features of voltage activation, voltage inactivation and recovery from inactivation that strongly resemble those of animal voltage activated Na+ currents (Figure 2B,C).
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It should be noted that the dark currents exhibited no discriminable response to changes in the bending radius, even though the X-ray-induced currents were slightly changed.
Furthermore, capsaicin-induced currents exhibited relatively fast activation and deactivation/desensitization phases as compared to RTX-induced currents, which exhibited significantly slower activation phase and deactivated/desensitized minimally even in the presence of extracellular Ca2+ [1].
We detected that while the inward currents were eliminated very rapidly, the outward currents exhibited changes within 30 min of treatment with scPPX1.
Both SA and Transient mechanically-activated currents exhibited graded increases in current amplitude in response to increasing the magnitude of indentation (Figure 1).
HetL164P currents exhibited greatly increased whole-cell currents that were unaffected by sulfonylureas.
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