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It also forecasts methotrexate exposures within the current dosing regimen to project the potential for toxicity and provide dosing guidance.
Current dosing approaches for treating microbial infections ignore resistant subpopulations.
However, the data do not support a clinically meaningful therapeutic benefit using the current dosing regimen.
Current dosing practices for warfarin are empiric and result in the need for frequent dose changes as the international normalized ratio gets too high or too low.
(Piasecki et al. 2015) Current dosing regimens of most drugs used in neonates, infants and children are derived from extrapolation of adult data rather than from systematic pharmacokinetic (PK /pharmacodynamics (PD) study of drugs in these populations.
The objectives of this study were to determine if this new dosing schedule can achieve the desired plasma concentration of tranexamic acid and reduce intra- and interpatient variability in tranexamic acid plasma concentrations relative to the current dosing schedule.
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To be clear, it is essential that women get their flu shots, even if the current dose is more than they need.
Patients taking Bupropion or Paroxetine at stage 1 will increase current doses.
The current dose rate seems to exceed the ITER requirement by a factor of 10.
In our series, the current dose of linezolid allows achieving the PK/PD target in patients with SRD and ILF.
Extending current dose finding designs to handle patient heterogeneity maximizes the utility of existing methods within a single trial.
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