But the likely cure observed in the Mississippi case has changed that risk-benefit ratio, presenting researchers with critical questions.
The epoxy resin was cured by heating with bisphenols in the presence of a catalytic amount of imidazole, with more rapid curing observed for more soluble bisphenols.
So, the post-cure observed can be ignored.
Since the microbiological assay seems to measure the total microbiological action, it was considered the more appropriate to measure the in vivo drug concentrations effectiveness, with the goal of correlating with the clinical and bacteriological cure observed on the clinical practice [ 15].
Moreover, no cures were observed with any of these chemotherapeutic agents.
No cures were observed and tumors regrew, reaching a mean of ~300 mm3 at Day 65 (when the experiment was terminated).
Following normothermia, tumour cures were observed at TNF concentrations of 1000-1300 micrograms kg-1, while this was observed at doses of 50-300 micrograms kg-1 when combined with hyperthermia (TCD50 values of 1211 and 188 micrograms kg-1 respectively), resulting in a TER of 6.4.
For example, raising the clonogenic cell density by a factor of 10 in a 10-g tumour will reduce the TCP of Y from 88%to28%8%, but as cures were observed in the larger tumours a clonogen density of 3×10 cells/g seems to be a reasonable estimate.
At 6 months after the end of treatment, paromomycin monotherapy provided only a 63.8% average cure rate with very low cure rates observed in 2 Sudan centers (14.3% and 46.7%).
Three different regions of curing were observed, corresponding to solvent evaporation; early stage curing, where the mass increases as oxygen is incorporated into the film; and long-term curing, where the mass decreases as volatile compounds are released.
