Even when treatment may be aimed at cure, long-term survival is only achieved in approximately one-quarter of patients.
Recent advances in our understanding of the biology of HIV have now allowed for proposals to recapitulate either a sterilizing cure (complete elimination of all HIV-infected cells from an individual) or functional cure (long-term control of HIV replication with HIV RNA <50 copies/ml in the absence of cART).
17, 24 Part of the reason for this is that, although clinical cure rates may be similar, microbiologic cure and long term efficacy are not.
However, the role of KALSOME™10 in prevention of reinfection after cure and long term protection from VL need further investigation.
With improved childhood cancer cure rate, long term sequelae are becoming an important factor of quality of life.
Even though direct intratumoral injection of IL-12 encoding plasmids resulted in significant immune response in different animal models [ 16, 35, 36], antitumoral response in a clinical trial remained marginal with no cure or long term immunity [ 37].
The field investigation confirms the findings of the laboratory testing and emphasizes the importance of wet curing for long term durability of concrete.
But this is the Catch-22 for a cancer patient: We must poison ourselves in the short term to hope for a cure in the long term, knowing full well we will get sicker before we get better.
For some types of oesophageal cancer, surgery alone or combined with chemotherapy offers the best hope of long term cure, but for other types similar long term cures are obtained with chemotherapy and radiotherapy.
It is not a long term cure for the structural problems," says Lazard investment banker Nicholas Shott.
However, strategies such as suppressive antibiotic regimens that attempt to eradicate persistence of BVAB, have not achieved sustained high long term cure [ 42, 43].
