The therapeutic concept at our institution was changed in 1997 to a more curative approach.
We propose that combined therapy of an HPMA copolymer-ALN-TNP-470 conjugate, can be used as a preventive or curative new concept of anti-angiogenic and antitumor treatment.
The alteration of the surgical approach in 1997 to a more curative treatment concept also had no influence (p = 0.67) on the overall survival.
Greater recognition of the concept of curative CPM should ultimately lead to earlier referral to specialist units, resulting in improved completeness of resection and better survival outcomes.
Preoperative chemotherapy is an attractive concept for obtaining curative resection.
Later, Kawaguchi et al. [ 2] proposed curative extensive resection, adopting the concept of "barrier on the basis of tumor-resistant tissue".
In Japan, Kawaguchi et al. [ 2] proposed in 1982 a technique for curative extensive resection, adopting the concept of barrier based on tumor resistance of fascia, periosteum, cartilage tissue, and other tissues.
Consequently, characterization of the molecular pathogenesis and development of innovative therapeutic strategies are imperatively required particularly since current approaches such as administration of Gemcitabine combined with Cisplatin are rather part of a palliative concept than a curative treatment strategy [ 7].
Traditional Uighur Medicine (TUM), a well-known medical system in China for their remarkable curative effect, is based on the concept of equilibrium and balance of natural body humors (blood, phlegm, yellow bile, and black bile).
The concepts of compartment and curative surgical margins are important for bone tumor staging.
Further general problems of the presented studies are their heterogeneity and lack of comparability with respect to the number of patients included, inclusion criteria (type of tumor, tumor stage), different treatment concepts (palliative treatment versus curative treatment including radical surgery) and different genotypes.
