Consequently, different indicators lead to a fear of future shortages, particularly among general practitioners: the decreasing productivity in young cohorts of registered doctors, the increasing proportion of active doctors who stop their curative activity before their retirement age and, finally, the retirement of substantial cohorts of graduates in the years 2015-2025 [ 8].
Curative activity Protection activity Compd.
Cancer chemotherapy remains the only treatment modality with curative activity against multiple forms of metastatic malignancy.
The antiviral tests indicated that some of the synthesized compounds possessed of moderately high curative activity against CMV.
Obviously, the presence of benzyl chloride groups can effectively enhance the curative activity of title compounds against TMV.
Moreover, some of the title compounds exhibited good curative activity against TMV in vivo at 500 μg/mL.
Compounds 7a, 7b and 7d indicated excellent protection and curative activities against TMV at 500 μg/mL.
In addition, compounds 3d, 3f, 3i and 3m showed better curative activities against TMV, with EC50 values of 152.8, 99.7, 127.1, and 167.3 μg/mL, respectively, which were better than that of ningnanmycin (211.1 μg/mL).
In addition, compounds 3d, 3f, 3i and 3m showed better curative activities against tobacco mosaic virus (TMV), with EC50 values of 152.8, 99.7, 127.1, and 167.3 μg/mL, respectively, which were better than that of ningnanmycin (211.1 μg/mL).
The majority of the synthesized compounds exhibited good levels of antiviral activity against the tobacco mosaic virus (TMW), with compounds 7a, 7b and 7d in particular providing higher levels of protective and curative activities against TMV at 500 μg/mL than the control compound ribavirin.
For example, compounds 3d, 3f, 3i and 3m, which contain respectively 2-ClPh, 4-ClPh, 2,4-di-ClPh and 2-Cl-thiazol-5-yl groups, exhibited excellent curative activities against TMV, with the EC50 values of 152.8, 99.7, 127.1 and 167.3 μg/mL, respectively, which were better than that of ningnanmycin (211.1 μg/mL).
