We have documented several informatics challenges during the curation of Medicago genome and presented our solutions to those challenges.
Literature curation of protein interaction data faces a number of challenges.
A significant level of phenotypic data, however, remains in non-phylogenetic studies, e.g., species descriptions, and methods for efficient EQ curation of this literature remain a critical challenge.
While continuous curation of molecular pathways remain a major challenge, the availability of Alzpathway through Payao (http://alzpathway.org/) would enable AD researchers to review, comment and provide feedbacks to the pathway through the web-based interface.
Curation of the evolutionary literature, however, presented a special challenge because it required distinguishing between author statements that were based on direct observation of specimens and generalizations to higher-level taxa.
The two founders faced significant scaling challenges, from how to establish guardrails around curation of the collection to go-to-market distribution channel strategy and customer acquisition strategy.
The principles and best practices for the curation of complex phenotypes that we have developed from this exercise are generally applicable, as are the challenges inherent in aligning rich textual descriptions with ontologies and syntactic relations.
Here, we present data, illustrating how InnateDB curation of the innate immunity interactome has greatly enhanced network and pathway annotation available for systems-level analysis and discuss the challenges that face such curation efforts.
The main challenge while developing the GeneStoryTeller was the construction of a robust synchronization mechanism for the continuous curation of the database.
Currently, literature curation is challenged by a lack of automated annotation techniques, particularly for Gene Ontology (GO) annotations (1).
Our business is the production and curation of knowledge.
