"We grew whisker hair on the ears and the paw pads of mice". Buckler quickly added that the majority of the new cup cells always migrate to the base of the hair follicle.
Hoffmann and McElwee are co-applicants of a landmark patent on the use of hair follicle cup cells and their use in hair diseases.
In 2012, RepliCel announced success in the first human clinical trial assessing the safety of injecting autologous dermal sheath cup cells (DSCC) — in essence the cells from a patient's own body suspended in a benign, saline-like solution.
58, 59 Apart from stalk cells and spores, D. discoideumhas three more cell types, the basal disc, upper cup cells and lower cup cells, that each display specific patterns of gene expression.
This suggests that there is no real biological hindrance opposing successful grafting of CUP cells on immunodeficient mice.
This thin epithelial layer composed of columnar absorptive cells, goblet cells, undifferentiated crypt epithelial cells, panet cells, enteroendocrine cells, tuft cells, cup cells, and intraepithelial lymphocytes [ 32].
Altogether, these results support the idea that Yap and Taz are necessary and sufficient to promote optic cup cells to adopt RPE cell fate.
By E12, the optic cup cells were uniformly Lgr5-EGFP+ and the majority of the Lgr5-EGFP+ mesenchymal cells had migrated to the vicinity of the optic cup and into the cavity between the optic cup and the lens vesicle.
A discrete sub-set of ALC/pstB that express ecmB from a distal element of its promoter migrate upwards to form the upper cup region of the early culminant (DDANAT:0000042), hence becoming upper cup cells (DDANAT:0000112) [ 61, 62].
