Genotypes associated with increased risk were: XRCC1 R194WW(WW and RW vs. RR, cumulative risk up to age 70, risk ratio (RR) = 2.3; 95% CI 1.3 3.8); XRCC1 R399QQ(QQ vs. RR, cumulative risk up to age 70, RR = 1.9; 1.1–3.9); and BRIP1 (or BACH1) P919SS(SS vs. PP, cumulative risk up to age 50, RR = 6.9; 1.6.99.3).
Cardiovascular diseases have both elements of cumulative build up, as well as sensitivity to immediate circumstances.
The cumulative score up to the first occluded sequence is initialized with T 1,−1=−∞ and T 1,+1=0.
characterized by a small thickness of individual layer (ranging between 0.1 m and 34.77 m), and large thickness of the total cumulative layers (up to 380 m).
According to the S-N curve of fatigue life of Berea sandstone, it is concluded that this deterioration evolution process of the rock sample is because the cyclic loads induced cumulative damage (up to 42% in maximum).
The estimated cumulative risk up to age 60 years for the development of cancer found as a result of surveillance at an interval of 2 3 years was 35%9595% CI, 16%49%%) in men and 22%9595% CI, 7%–34%) in women.
Indeed, it can be seen that the cumulative risk up to age 70 years is less than half the lifetime risk.
During a median follow-up of 5.7 years (cumulative follow-up time of 18 503 patient-years), 327 (11.3%) patients died.
To fill this gap, we review six up-and-down designs: the "3 + 3" design, accelerated titration design, biased coin design, k-in-a-row design, group up-and-down design and cumulative group up-and-down design.
Cumulative, joined-up data is simply not the same beast as data that's distributed and at least partially disconnected.
