In the cumulative scheduling problem (CuSP), an operation i requires a constant amount ei of processors throughout its processing.
The aim of this paper is to show the usefulness of the Jackson's pseudo-preemptive schedule (JPPS) for solving cumulative scheduling problems.
The most characteristic and dose-limiting toxicity of OHP is sensory neuropathy, which is dose cumulative and schedule related.
The clinical use of DOX, however, has been limited by the risk of cardiotoxicity, which is dependent on the cumulative dose/treatment schedule, typically refractory to common medications, and can be fatal [ 20- 22].
It has been known that Japanese centers use lower cumulative dose schedules with shorter overall treatment time (OTT) than those of US and Europe [ 27, 28].
In both Experiment 2 and Experiment 3 after habitual sleep, on the PR schedule, cumulative pressure difference between sweet and non-sweet beverage increased with difference in amount wanted in the taste test.
A "cumulative handling-time" schedule of reinforcement47 controlled the delivery of rewarding stimulation during data acquisition.
However, these agents are associated with increased risk of cardiovascular complications, dependent on cumulative dose and schedule, and are often irreversible.
It has been known since the 1970s that anthracycline treatment is associated with an increased risk of heart failure, and that this is dependent on cumulative dose and schedule [ 6].
For example, rates of grade 3/4 peripheral neuropathy up to 33 % have been reported in studies of patients treated with taxanes for breast cancer, although the specific incidence can vary depending on the particular agent, dose per cycle, cumulative dose, treatment schedule, and duration of infusion [ 17].
The present report concerns the systematical monitoring of cardiac functions performed in 136 patients enrolled into the above-mentioned randomised trial; we evaluated the relationship between schedule, cumulative dose of Epirubicin, type of prior adjuvant treatment and risk of developing a cardiotoxic event.
