Sentence examples for cumulative role from inspiring English sources

Collectively, these data suggest that both epigenetic and copy number disruptions play a cumulative role in deregulation of gene networks in OS cell lines.

The same acetyl-lysines in H3/H4 (except H3K14ac) are part of a "backbone" of 17 marks associated with active promoters at a genome-wide level in human T-cells [40] and, in yeast H4, have a non-specific, cumulative role in transcriptional activation [11].

The cumulative role of multiple vascular risk factors or diseases increased the risk of VaD, as noted by the total vascular index.

Although further functional studies are essential, our findings extend the understanding of the cumulative role of genetic and environmental factors in the colorectal carcinogenesis in the Asian population.

Increasing evidences in both experimental and clinical studies suggest that angiogenesis and oxidative stress play a cumulative role in the pathogenesis of malignancy.

This raises the vital question of the cumulative role of determining factors in the development of social inequalities with respect to health [ 17].

These analyses provide evidence of the cumulative roles of epigenetic and genetic mechanisms in deregulation of gene expression networks in OS cell lines.

In conclusion, these data provide evidence of the cumulative roles of epigenetic and genetic mechanisms in cancer-related deregulation of gene expression networks.

This first integrative analysis of global cancer-related changes in DNA methylation, genomic imbalance, and gene expression has provided comprehensive evidence of the cumulative roles of epigenetic and genetic mechanisms in deregulation of gene expression networks.

For example, the N-terminal tail of histone H4 has four acetylated lysines: K5, K8, K12, K16, of which H4 K5Ac/K8Ac/K12Ac play a non-specific, cumulative regulatory role different from that of H4K16Ac [ 60].

The role of pesticide poisoning in the apparent effects of cumulative use is still a question.