Edge t i,j represents the cumulative phenotype-cluster transition frequency between Nodes i and j due to either environmental perturbations or genetic perturbations.
Thus, edges t i,0 and t j,0 represent the cumulative phenotype-cluster transition frequencies to the nonviable-growth phenotype due to perturbations.
In addition to these desirable properties, the PAI contains useful information regarding the KWII because it represents the cumulative phenotype-associated synergy present in all subset combinations of the variables X1, X2,..., X K and P. In Results, we will demonstrate that both the KWII and PAI metrics are effective and efficient for GEI analysis.
ACR classification criteria reflect a cumulative clinical phenotype of SLE but not necessarily the picture at blood sampling.
Qualitatively, the figure resembles our observations for a single random walk, except that the absolute number of cumulative unique phenotypes encountered is higher in evolving populations.
Additional file 3 shows the average number of cumulative unique novel phenotypes accessible to a population through generation 2000.
Kaplan Meier curves were constructed for each major CS/CSL cancer phenotype for cumulative risk assessment, with significance determined by a generalized Wilcoxon's test.
This might reflect that endothelial-primed progenitors are more susceptible to the changing patient phenotype and cumulative therapeutic intervention than generic progenitor cells.
The age-dependent phenotypes suggest cumulative damage and this is consistent with our observation that dOpa1 mutation results in increased ROS production and accumulation in eyes[18].
The second observable was the cumulative number of new phenotypes that the circuits explored exclusively through mutation.
