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Over time, the difference in selection efficiency would lead to a greater cumulative deterioration of X-linked relative to autosomal nuclear genes as a result of mitochondrial mutation pressure (fig. 2).
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Besides, the model provides easy-to-evaluate expressions for important reliability quantities such as the density function and the moments of the lifetime, and the mean and moments of the cumulative shock deterioration at any time.
The major policy gap affecting management outcomes was the absence of a mechanism with which to manage cumulative impacts responsible for deterioration of key ecosystem processes and biodiversity.
Cumulative median time-to-radiographic deterioration was 9 years, and 5-year and 10-year rates of radiographic deterioration were 39.1% and 54%, respectively (figure 3).
When the severity of environment is compounded with poor quality concrete and/or defective design and construction practices, the process of deterioration becomes interactive, cumulative and very rapid, and a cancerous growth that cannot be easily stopped.
We used Kaplan-Meier estimates to evaluate the cumulative probability of acute clinical deterioration over 24 weeks on TB treatment.
Such mutational load can act in two not mutually exclusive ways: 1) through homozigosity of recessive deleterious alleles at particular loci or 2) by the cumulative load, and hence general deterioration, of the clonal genomes, independent of homozigosity [ 26, 36].
This model combines a post-peak negative stiffness branch of the backbone curve to capture in-cycle strain softening and a cyclic model to capture the strength and stiffness deterioration based on the cumulative hysteretic energy dissipated (Fig. 9).
Due to large number of load reversals the effect of cumulative damage on structural components due to deterioration becomes critical for steel buildings of old construction but may also become critical for buildings designed based on current seismic provisions.
The effect on the time-dependent cumulative fatigue damage as a function of corrosion deterioration is calculated.
"Most people have a level of resilience which allows them to function fairly well for a few months, but after that time there is a steady deterioration … after six months the cumulative harms accelerate very rapidly".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com