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S162A was not analyzed for this step or subsequent steps because of the magnitude of the cumulative defects from earlier steps.
Conversely, the absence of cell elongation of the Inv dinG mutants after a shift to LB contrasts with their plating defect suggests late, possible cumulative defects.
As the HRD score results from cumulative defects occurring in the genome of the tumour, it should not be sensitive to reversion mutations.
In total, 77 % (51 of 66 informative cases) of gastric cancers showed cumulative defects in these two dependence receptors and were significantly associated with chromosomal instability.
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There is evidence suggesting that at older maternal age, risk of other diseases is cumulative and genetic defects become more common leading to spontaneous abortions.
For although violence, abuse and the like may be a factor, what is more usual is a series of ostensibly blameless defects the cumulative effect of which is the mother of all hissy fits.
The cumulative size of the defects ranged from 9 x 11 cm to 12 x 18 cm.
All cancers result from the cumulative acquisition of molecular defects within a basic core of cellular functions that control proliferation, apoptosis, and invasiveness (Hanahan and Weinberg, 2000).
All together these data suggest that the deregulation of the cell cycle starts at late developmental embryonic stages and has cumulative effects resulting in major defects in brain development accompanied by perinatal death in triple mutant mice.
Figure 5 Cumulative probability functions of orthogonality defects (in logarithm) from 10, 000 random examples.
Cumulative increase in these genetic defects also provides prognostic assessment for disease outcome.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com