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We adaptively randomize patients to one of five treatments, basing the randomization probability on the cumulative data from the ongoing trial and fitting results from the regression model.
In adaptive optimal designs, each stage uses a locally optimal design evaluated at the maximum likelihood estimates derived using cumulative data from all prior stages.
We pay special attention to the cellular programs underlying appendage regeneration, where cumulative data from salamanders, fish, frogs, and mice indicate that regeneration occurs by the actions of lineage-restricted precursors.
Furthermore, the percentage of CD11b+F4/8 0+macrophages in PECs was comparable between WT and Rbpj cKO mice after chitin administration (one representative experiment shown in Fig. 1A and cumulative data from three independent experiments shown in Fig. 1B), suggesting that Rbpj deficiency did not significantly alter the total macrophage population in response to an M2 stimulus in vivo.
As measured by percentage of CD45+SiglecF+ cells as previously described (Satoh et al., 2010), chitin-induced recruitment of eosinophils was significantly reduced in Rbpj cKO mice compared with WT controls (one representative experiment shown in Fig. 1C and cumulative data from 6 pairs of mice shown in Fig. 1D), suggesting that Rbpj deficiency in the myeloid lineage impairs M2 macrophage function.
Cumulative data from five separate experiments shows RVG-9r peptide delivered PrP siRNA to 85±10% of N2a cells with a MFI of 200±31 (figure 3r), significantly more than RVM-9r peptide (7±4% with an MFI of 5±3) or liposome alone (20±4% with an MFI of 10±2, p<0.01), values not significantly different than untreated cells (grey square, 3±2%, MFI of 3±2).
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In North Carolina, we analyzed cumulative data for tuberculosis (TB) from 1980 through 1999 to determine trends in incidence, population subgroups at risk, and implications for health policy- makers.
In cumulative data collected from two independent experiments (n = 10 per group for experiment 1 and 9 CD14-KO and 10 WT for experiment 2), we find that following infection with Pb-A parasites, 16 of 20 (80%) WT mice developed ECM (Fig. 1A) by day 8.
Fig. 6C shows cumulative data obtained from four fibres exhibiting localised Ca2+ release events.
Cumulative data derived from the fasting state and the SFA postprandial state indicate that type 2 diabetic subjects are subjected to 336% more circulating endotoxin than NOC subjects over the 4-h duration.
The cumulative data were obtained from eight successive, five minutes apart.
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