Additionally, cyclosporine is not an option for long-term treatment of psoriasis, because of cumulative toxicity concerns.
This study presents 32 years of cumulative data concerning clinical presentation, laboratory findings and prognostic factors of bacterial meningitis from patients aged one month to 14 years of age.
Finally, reports of RCTs should follow the CONSORT recommendation (Schulz, Altman, & Moher, 2010) that all intervention procedures are described 'with sufficient details to allow replication' (p. 699) to facilitate cumulative knowledge concerning the effectiveness of BCTs.
All data concerning dose of medication and duration of mechanical ventilation concern cumulative data from admission to the ICU up to the time of measurement.
Both procedures generate similar results concerning cumulative emissions of tebuconazole, copper, dissolved organic carbon and total nitrogen.
However, there are important gaps in knowledge concerning cumulative exposure.
38 Our study suggests that routinely collected clinical data concerning cumulative comorbidity may be utilised to quantify risk; however, further work would be required to validate this as a tool for use in clinical care.
Although many residents seemed to be numbed by Tuesday's killing spree, more than a few said they worried that all the cumulative bloodshed and health concerns were giving Toms River a less-than-rosy reputation.
The second difference concerns the cumulative inactivation.
In addition, combination therapy may reduce safety concerns and cumulative toxicity, as lower doses of individual agents may be efficacious when used together.
