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Genes in each category were assigned a value of 1 or 0 and ranked according to their cumulative category score.
Since only four patients were not classified as having either severe sepsis or septic shock, we combined sepsis and severe sepsis in a new cumulative category 'sepsis without shock', as opposed to 'sepsis with shock'.
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To provide some sense of risk-by-severity of outcome, we categorized health outcomes into 3 cumulative categories: total illness, severe illness, and death.
Multivariable models were adjusted for potential confounders that were significantly associated with both depression in the univariate analyses and also associated with the three cumulative categories of exposure to any pesticide, an HPEE, or pesticide poisoning; the models excluded additional pesticide exposure variables to avoid bias due to overcontrol.
The cumulative hybrid category comprised 23 (10.0%).
Both the reference group and the low cumulative exposure category had a higher percentage of females, "white" race, officers, and college graduates than the medium and high cumulative exposure categories.
The only other significant association was for large cell carcinoma with an OR = 1.68 (1.03–2.74) at the highest tertile cumulative exposure category.
For example: When workers with "ever" exposure to gasoline were excluded, ORs were reduced in each cumulative exposure category and E-R trends of total lung cancers and cumulative exposure were reduced from p = 0.07 to p = 0.13), even though there was no E-R trend with gasoline (p = 0.68).
The estimated associations with non-Hodgkin lymphoma in that study are relatively imprecise, given the small size (n = 32 cases and 158 controls), but there is evidence of an association with any pentachlorophenol exposure (OR = 2.75; 95% CI, 0.45 17.0) and specifically with the high cumulative exposure category (OR = 4.19; 95% CI, 0.59 29.6).
Data extraction: Cumulative exposure categories and corresponding risks were abstracted.
However these results were based on two or three cases in the high cumulative exposure categories.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com