The reconstructed diameter was used to estimate the plot-level cumulated volume increment during the last 10 years.
Scenario E (' Evolution, mortality driven by low level of cumulated carbon reserve'), in which mortality only occurred when the carbon reserve at the end of the year (CumCR) fell below a critical value (Type I mortality, Table 1).
In our earlier studies we detected statistically significant associations between 24- and 48-hr cumulated personal exposure and levels of damaged DNA by repeated measurements in 15 50 volunteers (Sørensen et al. 2003a, 2003b; Vinzents et al. 2005).
Even when the first decline during follow-up was to an eGFR below 30 mL/min/1.73 m, 44% (45 out of 103) of metformin users in Denmark and 62% (281 out of 450) in the UK had a prescription for metformin within 90 days after the decline date (cumulated proportion across baseline levels ≥30 mL/min/1.73 m in table 4).
The SPECT scans were co-registered using a rigid mutual information algorithm, and these were used to obtain the time-activity curves and to calculate the cumulated activity at the voxel level.
Second, we calculated the cumulated arsenic exposure by cumulating the products of "arsenic level × time" for each address occupied during the total observation period and multiplied by the total daily intake of tap water, with the unit milligram (Equation 2).
We additionally created five metrics related to IBL that cumulated exposure only above increasing blood lead levels ranging from 20 to 60 μg/dL (IBL20 IBL60).
The variables included six continuous variables (age, duration of chemotherapy courses, interval between surgery and chemotherapy, cumulated dosage of oxaliplatin and mRNA expression levels of ERCC1 and TS) and eight categorical variables (sex, primary tumor location, tumor stage, tumor differentiation, lymph node staging, nerve invasion, vascular invasion and chemotherapy regimens).
The level of DNA damage and the cumulated exposure were cubic root transformed before the mixed-effects model analysis.
The subject level was a random factor, and cumulated exposure to UFPs occurring during bicycling, remaining time outdoors and indoors, and monitoring station values were tested as potential predictor variables with fixed effects.
