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However, this approach is hindered by lipopolysaccharide-associated cytotoxicity and cumbersome synthesis.
Furthermore, the enantiomeric purity of the product was not determined, limiting the applicability of this cumbersome synthesis route.
However, due to the cumbersome synthesis of F-galacto-cyclo RGDfK) and the requirement F-galacto-cyclo RGDfK-by cyclotron, this team began exploring alternative RGD derivatives using gallium-68 as the PET isotope with a variety oF-galacto-cyclo RGDfK
A novel, facile, high yield, and less cumbersome synthesis of riccardiphenol analogs is described.
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Their post-synthesis separation is cumbersome, and therefore a selective synthesis is desired.
Chemospecific and regiospecific modifications of natural products by methyl, prenyl, or C-glycosyl moieties are a challenging and cumbersome task in organic synthesis.
Since Cap and CAPanalogs are not largely available and their chemical synthesis is cumbersome, they have been obtained through a direct lipase-catalyzed reaction.
Synthesis of phosphatidylcholines containing DHA and propofol is also a possibility, but such a synthesis is more cumbersome.
The most faithful, if cumbersome, representation would be to model the synthesis of each protein from first principles, with bursts of transcription.
2a, 5. Likewise, the synthesis of sterically hindered, symmetrical salts is cumbersome.
However, as noncharacterized substances precipitate during the synthesis, a limitation of this method is the cumbersome maintenance of the synthesis module after each synthesis.
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