Thus, availability of a label-free, non-invasive platform to replace the current cumbersome manual selection has become a critical need.
Yet, since eukaryotic sex is a complex and cumbersome apparatus, selection for its evolution must have been particularly intense during its origin.
The current method of animal selection is cumbersome and inefficient, however, as animals are selected based on their phenotype.
The use of gradient based optimization techniques in finding the optimum solution of such large design problems is cumbersome due to the selection of initial design points and convergence difficulties while metaheuristic algorithms do not suffer such problems.
Gel-based electrophoretic fractionation (size selection) is cumbersome and not easy to scale up.
MMS allows you to send multiple images but the sending process is slow, and the selection process is cumbersome.
This expensive, cumbersome and time-consuming background selection can be avoided and substituted by another backcross with the recurrent parent, if necessary.
One obvious advantage of this type of strategy is to offer a therapeutic opportunity to a large number of subjects without the implementation of cumbersome and expensive means of selection.
In epidemiological studies, even with a moderate number of covariates, it is typically difficult to examine all possible interactions with standard regression techniques, because estimating a large number of parameters is required, and model selection quickly becomes cumbersome.
59 Though such methods show promise for tailoring specific models to complex problems with high accuracy, their application is cumbersome, as they require manual selection of genes for which we have prior knowledge.
