Sentence examples for cumbersome modification from inspiring English sources

This work provides a novel surface modification strategy to decorate a wide range of different substrates with polymer brushes, thereby eliminating the need for cumbersome modification protocols, which so far had to be established for each substrate material independently.

As for the cumbersome database modifications that need to be made, Mr. Gilbert said: "Our consultants say they are working on it, but they haven't gotten back to me with a plan.

This early example of synthetic biology relied on slightly cumbersome genetic modifications, with genomic insertion of Tn 5 into crtI exerting polar effects on the adjacent crtB gene [33], and plasmid-borne expression of the P. agglomerans crtI gene driven by the strong puc promoter [38] likely driving abnormal levels of transcription and enzyme production.

While this approach shows immune enhancement, the preparation of autologous DC for CCL21 genetic modification is cumbersome, expensive and time consuming.

Current methods for making synthetic interspecies hybrids are cumbersome and/or require genome modifications.

The revised system has further complications and becomes cumbersome as the complexity of side-chain modifications by biosynthetic alkylations increase.

Although at first glance cumbersome, it offers a structure that readily allows modification and extension.

Guidelines have emerged that would limit the maximum lifetime dose of anthracyclines and make a baseline assessment and periodic monitoring of cardiac function part of the routine practice, which could be cumbersome, and may condemn the patient to an unwarranted modification of his/her regimen.

Determining gene-specific patterns of histone modifications of cancer cells in primary tissue specimens can be cumbersome due to cellular heterogeneity and tissue quantity, and would involve high-throughput ChIP which may not be easily adaptable by clinical laboratories.

Because borrowers will be required to repay any assistance granted -- and because the amount to be repaid will be safely locked up as equity in the house, guarded by a lien -- there is no need to perform cumbersome manual evaluations of borrower financial positions to determine if borrowers truly deserve a modification.

Without a complete genome, identification of the specific methylase for DNA modification to resist restriction enzymes in the host cells is typically a tedious and cumbersome trial-and-error exercise.