Moreover, this approach is clearly less cumbersome than determination of the clinical gold standard of creatinine clearance derived from 24 h urine collection.
In addition it is quite cumbersome for routine determinations.
Because of the low prevalence of these infections in the general population, their determination is cumbersome because it would imply large sample sizes.
The scarce amount of data so far available is mainly due to the rather cumbersome methods for direct determination of circulating blood volume (CBV) in ICU patients.
George et al. [ 27] compared 4 evaluation methods in depressed patients treated in primary care and showed that an electronic medication event monitoring system (MEMS) for daily pill count was the most reliable method, followed by simple patient self-reports, while plasma level determination was cumbersome and quite inconvenient.
The anaesthetist can direct his/her full attention on vasoactive and volume therapy, which might sometimes be necessary in unstable CABG patients in the perioperative period, rather than be involved in cumbersome, time-consuming, intermitted thermodilution techniques of CO determination.
Whereas Kiefer and colleagues used pressure volume curves for PEEP titration, we titrated PEEP on the basis of improvement in oxygenation, which is a commonly used method in clinical practice because determination of pressure volume curves can sometimes be cumbersome.
The FC abluminal boundary is usually characterized by a gradual transition of pixel intensity from bright to dark, and visual determination of the optimal transition point can be cumbersome, inaccurate and subject to high variability.
The analytical solution requires the determination of roots of the characteristic equations, which is cumbersome for spherical particles.
As the laboratory determination of resilient modulus is costly, time consuming and cumbersome, several empirical models are developed for the prediction of resilient modulus for different regions of the world based on the database of resilient modulus values of local soils.
