In the same way, the combination of the internet, broadband-powered interactivity and the 3D printer could create a new nimble industrial era of individualised, localised goods escaped from the grip of huge manufacturing companies with vast capital investments and cumbersome making and delivery processes.
Previously, poor delivery, the cumbersome production of recombinant proteins and low reprogramming efficiency has hampered the widespread use of piPSCs.
Current methods of gene transfer for heart diseases include intramuscular (IM) injection into heart muscle and intracoronary delivery, which are cumbersome to apply.
At the dawn of the 21st century organizations such as the Institute of Medicine noted that delivery of health care was "cumbersome" (p.1), failing to "build on the strengths of all health care professionals" (p. 2), and as one of its six challenges, called for the need to develop effective teams [ 35].
Before we moved to Continuous Delivery, releasing to production was a slow, cumbersome process that involved a round of regression testing, collating a list of all the changes and a 12 step semi-automated process performed by a team who weren't involved in making those changes.
A researcher could have developed a vaccine strategy that is effective in human trials, and yet, is turned down at the delivery stage because the implementation is too costly or cumbersome (e.g., multiple shots per day, refrigeration required, careful follow-up, etc).
According to Ehrenfels' later account, Brentano's smooth and polished delivery did not impress him nearly as much as Meinong's cumbersome search for the truth (Ehrenfels in Fabian 1990, 426 429).
Health care delivery data already routinely supports health services research, but often requires cumbersome, inefficient, and costly data manipulation to do so.
