Ex vivo gene therapy using lentiviral vectors (LVs) is a proven approach to treat and potentially cure many hematologic disorders and malignancies but remains stymied by cumbersome, cost-prohibitive, and scale-limited production processes that cannot meet the demands of current clinical protocols for widespread clinical utilization.
This would make the whole process cumbersome and cost driven, not only for the physician but also for the patient.
It will be cumbersome and cost more to move.
And, it said, their plight is not satisfactorily remedied by currency-reading devices, which can be expensive and quite cumbersome: one costs $270 and has trouble reading $20 bills.
Others argued that as technology like software-enabled radios make it easier to communicate over the airwaves without interfering, such ownership rights are unnecessary and would only serve to limit the wide-ranging uses of the spectrum by requiring cumbersome transaction costs for whoever wanted to use it.
They're cumbersome and often cost extra for storage, which locks you into one studio or style of yoga.
Other techniques have been developed to overcome some of the drawbacks of the standard methods, such as high cost, cumbersome equipment, user bias, and limited replication.
Trying to do this across all 27 E.U. countries is incredibly cumbersome and hardly cost-effective.
"Potential investors should prepare themselves for significant security costs; cumbersome and confusing procedures for business visas or new business registration; long payment delays on some Iraqi government contracts; and sometimes unreliable, nontransparent dispute resolution mechanisms.
Differences within the systems include parameters such as operation (manual or automatic), handling (easy until cumbersome to use), and costs (e.g., expensive apparatus or high cost consumables).
