Sentence examples for cultured model from inspiring English sources

The reason for this discrepancy is not clear but could be attributed to the use of different doses of UCB challenges (50 µM versus 10 µM) or cultured model systems (astroglial cell cultures versus organotypic hippocampal slice cultures), resulting in stimulating different cellular processes that may vary in their mode of action.

In a cell cultured model, E.coli F18 infection failed to change the expression of TJ proteins (Fig. 1).

When delivered to cultured model host cells by an active T3SS, or via BioPORTER, Cif proteins induce the same phenotype, suggesting they recognise and act on a common substrate.

Gewirtz et al showed that the flagella of Salmonella enterica serovar Typhimurium triggers basolateral IL-8 secretion from cultured model epithelia via Ca++-mediated activation of the NF-κB pathway [13].

Using cultured model host cells as a system for infection it was shown that EPEC-Cif (CifEc) induces re-organisation of the actin cytoskeleton and triggers cell cycle arrests at either the G2/M (with associated doubling of DNA content) or G1/S phase transitions, in a T3SS-dependent manner [4], [5], [6], [7].

Also, this cellular system was used as an inexpensive and easy in vitro cultured model of stem cells [ 51, 54].

The use of related cell cultured models to investigate the genesis and development of epilepsy is beneficial for exploring the mechanism of epileptogenesis.

Here, we applied cultured models of mouse bEnd.3 cells coupled with Western blot analysis, selective pharmacological inhibitors, transfection with siRNAs, immunofluorescenct staining, and promoter assay to investigate the molecular mechanisms underlying ET-1-induced COX-2 expression and PGE2 release.

While ER activity was dominant in the LR and LTR derivates of our cultured models, we found that HER2 activity was crucial for resistance to T, as siRNA knocking down HER2 in our TR derivatives inhibited proliferation and also induced apoptosis.

Our recently described transcriptome signature for Ctx efficacy in cultured models of squamous cell carcinomas (SCCs) revealed that the molecular function of Ctx depended on high expression levels of genes encoding EGFR ligands (such as AREG and EREG) concomitant with downregulation of DUSP-regulated EGFR inhibition (Oliveras-Ferraros et al, 2011a, 2011b).

Co-cultured model of these two cell lines was established.