Efforts to identify the true functional culprit variants of PPARG (if different from rs1801282) are ongoing.
The two variants that we assessed are not necessarily the functional culprits.
Our data furthermore point to early pathological forms of Tau, including Tau oligomers, rather than somatic NFTs as culprits for the functional deficits.
Hypertension and hemodynamic overload are widely accepted as the main culprits of the cardiovascular structural and functional alterations and the cardiovascular disease, the leading cause of death in these patients [ 2].
Rare functional alleles are among the likely culprits (Pritchard 2001; Reich and Lander 2001) because power to detect association is a function of allele frequency and rare variants are underpowered when sample sizes are limited.
These approaches include expression quantitative trait loci (eQTL) and functional studies in tissues from patients with defined genotypes, which are essential to single-out the culprit gene at loci usually containing multiple transcripts.
Functional clothes for functional living.
Sometimes the culprit is technology.
