Osteoporotic fractures represent the culminating event of this devastating disease.
The tree (Figure 4b) has a hierarchical as opposed to a network structure, and represents a sequence of events occurring in time culminating in the outcome of interest.
Thus, a successful outcome culminating in ending the Gaddafi era was only a matter of time.
The events that unfold from their bold moves, often culminating in successful outcomes, make for gripping narratives.
Inhibition of HDAC activity reverses these outcomes, culminating in the accumulation of acetylated histones that promote the apoptosis of malignant cells.
Similarly, fibroblast activation and differentiation to a contractile myofibroblast phenotype is important for wound closure and ECM deposition; however, if this tissue repair phase does not properly terminate, persistent myofibroblast activation can lead to excessive wound contraction and ECM deposition, again culminating in a fibrotic outcome (Gurtner et al., 2008; Serini and Gabbiana, 1996).
As a result, different choices made at each stage of the process culminate in different outcome products.
The increase in sFlt-1 and 8-epiPGF2α in PE is an indication that these markers may play a synergistic role in the pathogenesis of PE and may be responsible for the widespread endothelial dysfunction culminating in these adverse pregnancy outcomes.
Our work underpins the concept that alcohol in HIV/AIDS has a critical role in regulating inflammation, mitochondrial dysfunction and cytotoxicity that can culminate in neurodegenerative outcomes.
In cancer, their inhibitory role in limiting immune response against "pseudo-self antigens" from tumor origin avoids an effective antitumoral immune response and often culminates into negative outcomes for the patient.
This phase will involve preparatory work, including review of the relevant scientific literature pertaining to adverse geriatric outcomes in the acute hospital, culminating in a 2-day workshop with a panel of clinical experts.
