Sentence examples for culminating in a failure from inspiring English sources

Perturbation of central signaling pathways, e.g., suppression of the nuclear factor kappa B (NF-kB), disrupts airway-branching and impairs development of epithelial, mesenchymal, and endothelial cell structures culminating in a failure of lung development [81 83].

The perturbation of central signaling pathways by the described inflammatory response is linked to the disruption of airway-branching and impaired development of epithelial, mesenchymal and endothelial cell structures, culminating in a failure of lung development as shown in fetal mice [14,15].

The inability of ESCRT mutants to increase the protein levels of vacuolar proteases appears to culminate in a failure to boost the catabolic activity of vacuoles early during starvation.

Detailed morphometric analysis of the spermatogenic defect in DAZL-deficient rats revealed normal numbers of spermatogonia, but reduced numbers of spermatocytes and round spermatids in their seminiferous tubules, culminating in a severe failure to produce elongating spermatids (Fig. 1A, B).

The US is to push ahead with military rescue operations in spite of a series of recent failures, culminating in a failed Yemen attack that left up to 13 dead, including American photojournalist Luke Somers and South African teacher Korkie.

Eventually, the onset of rock failure initiates a progression of mechanisms culminating in a critical state where an unstable condition is reached.

The trials were plagued with serious engine trouble, culminating in the failure of an entire turbine on 2 November.

Brabants' form suffered last year as he struggled with illness and a serious shoulder injury, culminating in his failure to earn selection for the 2011 World Championships.

Instead of being ushered in to see the president through the front door of the White House, the Russian leader merely saw Mr Bush senior during a stop-by visit at the National Security Council.This slight culminated in a more fundamental failure: while America was still hoping that Mr Gorbachev could reform the Soviet system, Russia and the rest were declaring independence.

Patients with cirrhosis are admitted to intensive care units (ICUs) for complications of portal hypertension such as variceal bleeding or hepatic encephalopathy, or for sepsis resulting from spontaneous bacterial peritonitis, chest or urinary tract infections, culminating in multiple-organ failure in a large proportion of patients.

The first was his troubled first two years, culminating in the failure of his health care plan and the Republican takeover of Congress.