Classes of trials with fewer discrepancies have found progressively smaller effect sizes, culminating in discrepancy-free trials reporting an effect size of zero Cite this as: BMJ 2014 348 g2688.
Mr. Thomson observes that "the movies had always loved new special effects" — "Citizen Kane," for one, is full of them — but "in the years after about 1970, the ability of these effects, culminating in computer-generated images, to release violence was beyond question and out of control": "all too often, it was a 'fun ride' separated from pain, damage and consequence".
Observational studies of hypothalamic DBS (hBDS) seemed to report slightly better results, but also more serious side effects, culminating in fatal cerebral haemorrhage in one patient.
These agents alter the trajectory of neurodevelopment and formation of neural circuits through a family of mechanisms targeting cell replication and differentiation, axonogenesis and synaptogenesis, and functional development of neurotransmitter and neurotrophin systems, culminating in adverse effects on behavioral performance.
Multiple mechanisms of action possibly underlie the benefit of an iPS cell-based intervention, including putative differentiation into cardiomyocytes, vasculature and/or paracrine effects, culminating into induction of an innate regenerative response.
Organophosphate (OP) pesticides damage the developing mammalian brain through multiple mechanisms that disrupt neural cell replication and differentiation, culminating in adverse effects on behavioral performance (Slotkin 1999, 2004, 2005).
Because Hairy1 is a primary target of miR-9, regional specificity is generated downstream of hairy1, culminating in the differential effect on apoptosis in the forebrain versus the hindbrain.
That effect culminates at the top-floor library, where a long, narrow terrace extends out underneath the building's steel canopy.
These effects culminate in growth restriction that may have multiple effects throughout the life of children.
Around mid-October the market tends to pick up steam again, culminating with the celebrated "January effect," which often begins as early as in December.
