It could provide some cues for the development of novel implantable biomaterials, such as tissue-engineered scaffolds for cartilage replacement, where specific cell alignment is needed.
Cells rely on the extrinsic meso-, micro-, and nano-scale chemistry and topography of their surroundings to provide the necessary physiological cues for their development and survival.
In this study, we proposed the laminin-coated matrix nanotopography platforms (LMNPs) that generate extracellular physical and chemical cues for neuronal development.
Overall, this report provides new insights into our understanding of motor control, as well as into practical cues for the development of huge databases of letters and words to train and test on-line handwriting classifiers and recognizers.
They suggest that gaze and infant-directed speech, experienced together, are powerful cues for the development of early social skills.
Incubation temperature is the initial cue for sexual development in TSD, in contrast to genetic sex determination (GSD) that is evident in a number of vertebrate groups such as amphibians, snakes, birds, and mammals [ 22].
Our study imparts new design principles on the role of nanotopographical and chemical cues in neuronal development for the fabrication of neuroprosthetic scaffolds.
If genes required for external genital development were expressed in the cloaca before the evolution of a phallus, then sustained exposure of these cell populations to a proliferative cue may have been sufficient for development of a patterned genital organ.
Because polyphenism is the extreme example of how development deviates from a linear genetic blueprint, it demands a genetic explanation for how environmental cues shunt development to hypothetically alternative modules.
However, dopaminergic neurotransmission appears to be essential for development of conditioned preference for ethanol-associated cues [ 54].
For example, PtOPT10 displayed especially high expression levels in internode 2. Grape and wine production is strongly affected by environmental cues during the development of the plant.
