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The first controls how fast an animal grows and depends on insulin or similar hormones to cue cells to grow and divide.
After 24 h of treatment with CuE, cells were harvested and fixed in 70% ethanol overnight.
Thus, if MMPs are activated on cue, cells that have failed to respond to first phase apoptotic signals will still be induced to die by detachment-induced apoptosis.
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We also discuss the importance, incorporation, and assessment of biomolecular cues, cells, and mechanical stimulation for such tendon-inspired materials.
In response to environmental or biological cues, cells release contents of secretory granules into an extracellular medium to communicate with or impact neighboring or distant cells through paracrine or endocrine signaling.
To polarize and migrate up the chemotactic gradient after sensing chemical cues, cells restrict filamentous actin (F-actin) polymerization and form a leading edge.
It is often thought that in the absence of external cues, cells extend pseudopodia in random directions, and that spatial cues such as chemoattractants induce a bias in the size or direction of the pseudopodia [2].
As early as 1953, however, it was shown that in the absence of external cues, cells exhibit a so-called correlated random walk [3], an observation that has been reproduced for nearly all moving cells [4] [7].
In the absence of external cues, cells move in random directions, but with a strong element of persistence that keeps them moving in the same direction Persistence allows cells to disperse over larger areas and is instrumental to enter new environments where spatial cues can lead the cell.
By using microfabricated topographic cues, cell-material interaction can be studied in a more systematical way.
Design of biomaterials for cell-based therapies requires presentation of specific physical and chemical cues to cells, analogous to cues provided by native extracellular matrices (ECM).
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