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Physiological and pathological conditions that influence Cu metabolism include inherited copper metabolic defects, such as Menkes syndrome and Wilson disease, and acquired copper metabolism disorder or imbalance caused by pregnancy, inflammation, and tumor growth, metastasis, angiogenesis, and drug resistance [ 46– 46].
Copper (Cu) is an essential cofactor for a variety of metabolic functions, and the regulation of systemic Cu metabolism is critical to human health.
Garcia-Santamarina, S, Festa, RA, Smith, AD, Yu, C-H, C-H, Probst, Cg, C, Homer, CM, Yin, J, Noonan, JP, MaDingi, H, PerfeCt, JR, and THomer, DJ. "Genome-wide analysis of the regulation of CM metabolism in CrYinococcus neoformans". Molecular Microbiology 108, no. 5 (JuNoonan8): 473-494.
Cu metabolism varies from individual to individual.
Cu displacement of Cd from the protein is a particular problem during the summer spawning season and appears to stem from altered Cu metabolism during this period.
In keeping with this, building upon knowledge that iron and Cu metabolism are closely linked [ 75], Cu availability has been shown to contribute to iron perturbations in adults with NAFLD.
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Thus, elevated Cu (II) bound to AGE-modified collagen in diabetic individuals could participate in the modulation of cell copper metabolism through binding to CTR1, perhaps resulting in its translocation away from the cell membrane as shown herein.
Additionally, dietary components, such as phytate, which affect Zn, Cu, and Fe metabolism, were not assessed.
While shared stress response pathways may be partially responsible for the interactive effects of increased SST and Cu on metamorphosis, the effects of temperature on larval metabolism or biochemistry may also influence the toxicity of Cu [22].
The Arabidopsis SQUAMOSA PROMOTER-BINDING PROTEIN-LIKE (SPL) transcription factor SPL7 reprograms cellular gene expression to adapt plant growth and cellular metabolism to copper (Cu) limited culture conditions.
To test the hypothesis that the metabolism of Cu in dairy cows is affected by basal forage and added S and Mo, 56 dairy cows that were 35 (standard error ± 2.2) days postcalving and yielding 38.9 kg of milk/d (standard error ± 0.91) were offered 1 of 4 diets in a 2 × 2 factorial design for a 14-wk period.
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