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If this difference was proved to be a critical factor in determining the intracellular location of the CTF, a certain sequence that is responsible for locating the CTF in the cytoplasm may be present.
Indeed, it has been reported that expression of wt 611-carboxy-terminal fragments (CTF) in the mouse mammary gland led to the development of aggressive tumors [7], suggesting a causal role for CTF in tumorigenesis based on their ability to constitutively homodimerize.
This has led to the establishment of CTF in various regions around the world.
These results demonstrate the potential applicability of the CTF in solid-state laser lighting devices.
For starters, the government provided an initial incentive to open a CTF in the form of a voucher worth £250 or more.
The benefits of CTF, in terms of productivity and sustainability, have been the subject of intensive research for a number of decades.
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Indeed, we found decreased levels of all γ-secretase components except PS2-CTF in the adult brain.
As a control for the inhibitory effect on PS, we observed an accumulation of N-cadherin-CTF in cultures infected with LV-PS1 D385A (Fig. 2A).
While we observed a trend towards increased APP-CTF in Pik3c3 siRNA treated cells, we found no significant differences (Fig. 4F G).
We similarly found that TAPI-1, but not the BACE inhibitor GL189, inhibits the DAPT-induced accumulation of neurexin-CTF in HA-βNrx1 or HA-βNrx2-transfected cells (Fig. 1C).
These results, which agree with our previous observations of accumulation of APP-CTF in synaptic terminals in PS1 cKO mice [38], indicate that PS regulates γ-secretase-dependent processing and accumulation of neurexin-CTFs at synaptic compartments.
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