For example, insertions of five alanine residues between CTD diheptads in yeast, which alter the CTD's overall tandem structure and physically separate core functional units, dramatically reduce growth rate and result in abnormally large cells that accumulate increased DNA content over time.
We ask external databases that use MEDIC to cite CTD as a source and provide a direct link from their disease page to CTD's disease page, to promote global data integration.
Yet some parents of children with NPC are supportive of CTD's proposed trial and equally adamant that the IV route should be an option.
The Pfizer articles complemented CTD's routine chemical-centric approach to article selection (14).
From CTD's perspective, the completeness of the MEDIC vocabulary is defined by its ability to capture OMIM-to-gene associations.
To test this concept, participating groups developed Representational State Transfer /BioC-compliant Web services tailored to CTD's NER requirements.
Each interface was then evaluated based on functionality and ease-of-use by CTD's biocuration project manager.
The result is CTD's 'merged disease vocabulary' (MEDIC), a unique resource that integrates OMIM terms, synonyms and identifiers with MeSH terms, synonyms, definitions, identifiers and hierarchical relationships.
If the article warranted curation, the biocurator searched PubMed using the article's title to retrieve its PMID and begin curation with CTD's Curation Tool (5).
Table 3 provides a summary of each team's approach to NER and IR; CTD's pipeline is also described in Table 3.
Although collaboration is planned with Group 116 to explore the feasibility of disease recognition tool integration, CTD's text-mining pipeline will remain largely intact for the foreseeable future.
