Suggestions(1)
Exact(14)
Tibbe et al. [ 36] used a theoretical model with equal death risk for all patients with true CTC in their blood circulation (regardless of CTC level) and got rather extreme (unrealistic) results.
At follow-up sampling after 3 4 weeks of therapy, patients with a CTC level ≥ 5 at baseline whose CTCs were reduced to < 5 had equivalent progression-free survival and OS to patients who began treatment with < 5 CTCs.
The CTC level was not correlated with the CEC level, P = 0.74.
Detectable preoperative CTC level did not reflect the lymph node metastasis status (pN0 versus pN1-2).
Detectable CTC level reflected metastasis to lymph nodes (pN1-2) with statistical significance (P value = 0.049).
The CTC level, AFP value of 400 ng/mL, and presence of macrovessel invasion were used to dichotomize for univariate analyses.
Similar(46)
This might contribute to the apparent association between high postoperative CTC levels and poor prognosis, as high CTC levels could signify more systemically advanced disease.
Although Chen et al (2004) were unable to show any prognostic significance of preoperative and intra-operative CTC levels (see above), they too found late postoperative CTC levels to be a highly significant indicator of outcome.
Although previous analyses have demonstrated some prognostic significance for CTC levels in portal blood sampled intraoperatively (Katsuno et al, 2008), studies assessing the significance of preoperative CTC levels have shown little predictive value in terms of clinical outcome (Wharton et al, 1999; Tsavellas et al, 2001).
The key question is whether the CTC levels and characters would be beneficial to the clinical decision.
Our data suggest that a refined differentiation between patients with different CTC levels is reasonable.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com