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Xylitol was crystallized using antisolvent crystallization technique in the presence of various hydrophilic polymer additives, i.e., polyethylene glycol (PEG), polyvinylpyrrolidone (PVP) and polyvinyl alcohol (PVA) at a range of concentrations.
The objectives of the present research were to prepare directly compressible paracetamol (DCP) by nontypical spherical crystallization technique and spherical crystals of aceclofenac (SCA) by typical spherical crystallization technique.
Engineered paracetamol crystals were obtained using antisolvent crystallization technique in the presence of various concentrations (0.1, 0.5 and 1%, w/w) of additives, namely, polyvinyl alcohol (PVA), Avicel PH 102 (microcrystalline cellulose), Brij 58, methylcellulose (MC) and polyethylene glycol having different molecular weights (PEGs 1500, 6000 and 8000).
We envisage that future work will address the incorporation of nucleation and crystal growth models on the full characterization of the crystallization technique.
Cilostazol crystals with different habits were prepared by solvent:anti-solvent crystallization technique.
In an attempt to improve the physicochemical properties of poorly aqueous soluble ezetimibe, its pharmaceutical co-crystals were successfully engineered with different crystal forming agents; benzoic acid and salicylic acid in equimolar ratios by solution crystallization technique.
Similar(33)
For instance, the bromodomain of the PF10_0328 protein from Plasmodium falciparum would not crystallize using typical crystallization techniques.
With the help of some novel crystallization techniques that used lipids to crystallize the entire complex, MacKinnon's team found that T1 and β helped stabilize the channel protein during crystallization without requiring support from antibodies.
The results show that in principle all molecules can be crystallized and confirm that different classes of platform chemicals require different crystallization techniques.
A broad range of crystallization techniques is generally employed to search for the most stable crystal form in hundreds or (in some cases) thousands of experimental attempts.
In this paper, various crystallization techniques in wastewater treatment are summarized, mainly including evaporation crystallization, cooling crystallization, reaction crystallization, drowning-out crystallization and membrane distillation crystallization.
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