The hierarchy of repeat-unfolding within fibrils is controlled not only by their relative mechanical stabilities, as found for single molecules, but also by the strength of cryptic interactions between adjacent molecules that become activated by stretching.
Our results exemplify the concept that quantitative, functional analyses carried out on a single cell level can uncover cryptic interactions of potential importance at the ecosystem level, and NanoSIMS and other single-cell enabled microbial activity tools (Samo et al., 2014) are essential to collect such data.
To address the possibility of cryptic interactions, a T3 was constructed to carry the T7 ligase gene instead of its own (experiment not described above).
Therefore, in the context of genome-enabled prediction [ 13], ANN are theoretically able to account for cryptic interactions between genotypes and phenotypes without the need of explicitly specifying a fixed genetic model [ 7], thus the genetic architecture of the trait can remain unknown a priori.
Here, the regression function, f (x i 1, x i 2, …, x i p ), should be viewed as an approximation to the true unknown genetic values, { g i } i = 1 n, which can be a complex function involving the genotype of the ith individual at a large number of genes as well as cryptic interactions between genes and between genes and environmental conditions.
In a previous study, it was shown that non-linear neural networks outperformed a benchmark linear model when predicting phenotypes, especially in inbred wheat lines where cryptic gene interactions are expected [ 14].
Frietze KK, Pappy AL, Melson JW, O'Driscoll EE, Tyler CM, Perlman DH, et al. Cryptic protein-protein interaction motifs in the cytoplasmic domain of MHCI proteins.
Nek8 does not contain an obvious NLS suggesting that nuclear uptake is a result of either a cryptic NLS or interaction with a partner that undergoes nuclear trafficking.
In the presence of all domains in the full-size YciR, however, the GGDEF domains of YdaM and YciR did not interact, that is, this interaction seems cryptic or conditional.
However, DNA barcode data can provide the earliest clues to the presence of cryptic host-parasitoid interactions that can be targeted for future taxonomic and ecological study [ 39, 40].
