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Crude applications of the psychiatric model of ME may have caused a lot of damage, but they are in line with common perceptions of ill-health.
Metaphor is also perhaps more directly (and brutally) found in the similarity between the circles on Mother Gaby's dress design, and the clothes hangar coiled atop the doom-o-meter, for crude applications along the lines of dilation, regret and termination, which one needn't describe precisely herein.
However, not only different definitions result in different prevalence rates, but also crude applications and diverse – often not indicated – modifications of the original definitions exacerbate this situation (see Additional File 2).
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In the present article modern methods have been developed and optimized for crude oil applications.
The problem is not the restrictions imposed by physics, but our still crude application of those physical laws.
As the aroma of truffle wafted up, I first feared a crude application of truffle oil, but the flavors were too deep and complex for that.
A number of UK-based scientists, including Stephen Curry, Dorothy Bishop and Athene Donald, have been prominent among those calling for an end to the crude application of impact factors.
Also, the crude application of economic incentives to change doctor and patient behaviors can backfire (e.g., changing diagnostic codes to maximize revenue or avoiding care for sick and expensive patients).
However, with regard to medicines for rarer indications, it is worth emphasising that the crude application of utilitarian approaches that favour funding research and treatments for common disorders could become a major barrier to further progress in cancer treatment.
The crude paint application, which left areas of raw canvas exposed, was appalling to viewers at the time.
For crude extract application, the lowest absorbance for clarity 0.04 was achieved under the conditions: 30°C, 20 min, and enzyme volume 0.15% (v/v), corresponding to a 98% reduction of limpid juice in nature.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com