The problem is not the restrictions imposed by physics, but our still crude application of those physical laws.
As the aroma of truffle wafted up, I first feared a crude application of truffle oil, but the flavors were too deep and complex for that.
However, with regard to medicines for rarer indications, it is worth emphasising that the crude application of utilitarian approaches that favour funding research and treatments for common disorders could become a major barrier to further progress in cancer treatment.
Crude applications of the psychiatric model of ME may have caused a lot of damage, but they are in line with common perceptions of ill-health.
Metaphor is also perhaps more directly (and brutally) found in the similarity between the circles on Mother Gaby's dress design, and the clothes hangar coiled atop the doom-o-meter, for crude applications along the lines of dilation, regret and termination, which one needn't describe precisely herein.
However, not only different definitions result in different prevalence rates, but also crude applications and diverse – often not indicated – modifications of the original definitions exacerbate this situation (see Additional File 2).
There is no feeling of easy flow, no attempt to disguise the fact that this has been a laborious build up of paint, an extended act of raw application of crude colour.
The crude paint application, which left areas of raw canvas exposed, was appalling to viewers at the time.
For crude extract application, the lowest absorbance for clarity 0.04 was achieved under the conditions: 30°C, 20 min, and enzyme volume 0.15% (v/v), corresponding to a 98% reduction of limpid juice in nature.
In the present article modern methods have been developed and optimized for crude oil applications.
The tools they had were crude, but the application of enough time and money to the problem, they thought, would yield the blueprint of humanity.
