Sentence examples for crucial trigger of from inspiring English sources

Indeed, multiple psychological studies suggest that a crucial trigger of creativity is the experience of unusual and unexpected events.

Since inflammation of visceral fat is a crucial trigger of atherogenesis, decreased visceral fat in PGC-1α-deficient mice may explain why these mice do not develop enhanced atherosclerosis.

Structurally it is closely related to α-synuclein and shares its ability to aggregate in vitro 16, 17 and in vivo, 18 which is believed to be a crucial trigger of neurodegeneration in α-synucleinopathies.

All these observations lead to a really complex but fascinating picture, where mitochondrial Ca2+ signals represent crucial triggers of apoptosis.

Crucial triggers of this new layer of post-transcriptional regulation are 'decoys' - or miRNA 'sponges' - including both coding and non-coding RNAs, such as pseudogenes, large intergenic ncRNAs, and circular RNAs [ 19, 22- 24].

Even though there is an equal possibility for genes that are deleterious to be switched on through changes in the enzymes that alter the epigenome, it would seem that the switching off of genes is the crucial trigger for the progression of tumours through altering the inherent stable balance in cells.

Hypoxia and HIF, major contributors to the pathogenesis of PH, have been thought to act as crucial triggers for miRNA dysregulation in PH.

Under such conditions, the effect of an activating microenvironmental stress becomes a crucial trigger.

Taking into account that both NKG2D and NKp44 on the cell surface may be down-modulated by sMICA, it is viable to consider that circulating sMICA could be affecting the integration of different crucial triggering signals in NK cells.

Although the mechanisms of cell loss are being uncovered the crucial triggers that modulate epithelial turnover through regulation of cell loss remain undetermined.

However, despite clear evidence that vaccination with mimetic microbial antigens has the potential to activate autoreactive T cells, crucial evidence for triggering of autoimmunity by mimetic sequences in natural pathogens is wanting.